25-Hydroxyvitamin D3 1-alpha-Hydroxylase

A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).

Also Known As:

25 Hydroxyvitamin D3 1 alpha Hydroxylase; Calcidiol 1 Monooxygenase; CYP27B1; 25-Hydroxycholecalciferol-1-Hydroxylase; 25-Hydroxyergocalciferol 1-alpha-Hydroxylase; 25-Hydroxyvitamin D 1-alpha-Hydroxylase; 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase; 25-Hydroxyvitamin D2 1-hydroxylase; 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol; 1-alpha-Hydroxylase, 25-Hydroxyvitamin D; 1-hydroxylase, 25-Hydroxyvitamin D2; 25 Hydroxycholecalciferol 1 Hydroxylase; 25 Hydroxyergocalciferol 1 alpha Hydroxylase; 25 Hydroxyvitamin D 1 alpha Hydroxylase; 25 Hydroxyvitamin D2 1 hydroxylase; Cytochrome P 450 CYP27B1; 25-Hydroxycholecalciferol 1-Hydroxylase; Calcidiol 1-Monooxygenase; Cytochrome P-450 CYP27B1; Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Oxidoreductases: 13899
    - Oxygenases: 336
      - Mixed Function Oxygenases: 2207
        Cytochrome P-450 Enzyme System: 5452
        Steroid Hydroxylases: 11
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase: 422
        Cytochrome P450 Family 27: 9
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase: 422
- Cytochromes: 2210
  - Cytochrome P-450 Enzyme System: 5452
    - Steroid Hydroxylases: 11
      - 25-Hydroxyvitamin D3 1-alpha-Hydroxylase: 422
    - Cytochrome P450 Family 27: 9
      - 25-Hydroxyvitamin D3 1-alpha-Hydroxylase: 422
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Hemeproteins: 196
    - Cytochromes: 2210
      - Cytochrome P-450 Enzyme System: 5452
        Steroid Hydroxylases: 11
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase: 422
        Cytochrome P450 Family 27: 9
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase: 422

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Disease

Drug/Important Bio-Agent (IBA)